Synthesis of a Novel Benzosuberene Analogue as an Anti-Cancer Agent

dc.contributor.advisorPinney, Kevin G.
dc.contributor.authorLu, Chi-Han (Thomas)
dc.contributor.departmentBiochemistry.en_US
dc.contributor.otherBaylor University.en_US
dc.contributor.otherHaichan Niuen_US
dc.contributor.schoolsHonors College.en_US
dc.date.accessioned2015-06-02T15:29:21Z
dc.date.available2015-06-02T15:29:21Z
dc.date.copyright2015
dc.description.abstractCancer is a highly prevalent disease characterized by abnormal growth and uncontrolled division of cells. While many current treatments modalities are powerful in their ability to damage and potentially destroy tumors, most therapeutic strategies lack selectivity towards cancer cells and unfortunately also damage normal healthy tissue. The search for anti-cancer agents that possess enhanced cytotoxicity and high selectivity has led to the discovery of benzosuberene-based analogues, of which certain analogues are potent vascular disrupting agents (VDAs) that destroy tumor vasculature and thus deprive the tumor of necessary nutrients and oxygen. The purpose of the project is to synthesize a novel benzosuberene analogue that is based on a lead compound (referred to as KGP18) discovered by the Pinney Research Group (Baylor University) and incorporates designed structural modifications. The ultimate goal is to obtain a new small-molecule, benzosuberene-based anti-cancer agent that demonstrates improved biological activity as both a cytotoxic (antiproliferative) agent and a functional VDA. While the project is ongoing, the chemical reactions that have been performed to date were successful. The current synthetic pathway suffers from low yield, thus one future direction involves modification of the synthesis in order to obtain greater efficiency. Upon completion of the synthesis, the novel benzosuberene compound will be subjected to biological evaluation (in collaboration with the Trawick Research Group, Baylor University) to analyze its cytotoxicity as an antiproliferative agent and selectivity as a potential VDA.en_US
dc.identifier.urihttp://hdl.handle.net/2104/9388
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsWorldwide access.en_US
dc.rights.accessrightsAccess changed 1/7/2019.
dc.subjectInhibitors of tubulin assembly.en_US
dc.subjectBenzosuberene-based anti-cancer agents.en_US
dc.subjectVascular disrupting agents.en_US
dc.titleSynthesis of a Novel Benzosuberene Analogue as an Anti-Cancer Agenten_US
dc.typeThesisen_US

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