Pharmacophore-directed retrosynthesis applied to salarin C and phainanoid F.

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dc.contributor.advisorRomo, Daniel.
dc.creatorWoods, James Evan, 1994-
dc.date.accessioned2024-07-17T14:15:43Z
dc.date.available2024-07-17T14:15:43Z
dc.date.created2023-08
dc.date.issued2023-08
dc.date.submittedAugust 2023
dc.date.updated2024-07-17T14:15:47Z
dc.description.abstractThis dissertation describes a new approach to total synthesis, namely pharmacophore-directed retrosynthesis (PDR), applied to two natural products. The first chapter focuses on the history of the potent antiproliferative agent, salarin C (SalaC). This includes the isolation, bioactivity, instability and previous synthetic work performed on SalaC. Chapter Two describes our successful work regarding the synthesis of two model macrocycles and subsequent stability studies. Chapter Three encapsulates a brief review of dammarane-type triterpenoids (DTTs) in general and, more specifically, 13,30-cyclodammarane natural products. DTTs display a wide range of biological activity, including anti-cancer,1-2 anti-viral,2 and immunosuppressive activity.3-4 Chapter Four defines PDR and outlines its applicability with respect to phainanoid F and related DTT natural products, including known SAR, the hypothetical pharmacophore, and our planned derivatives. Finally, Chapter 4 also encompasses our synthetic studies toward the derivatives and synthetic intermediates with potential biological activity.
dc.format.mimetypeapplication/pdf
dc.identifier.uri
dc.identifier.urihttps://hdl.handle.net/2104/12844
dc.language.isoEnglish
dc.rights.accessrightsNo access – contact librarywebmaster@baylor.edu
dc.titlePharmacophore-directed retrosynthesis applied to salarin C and phainanoid F.
dc.typeThesis
dc.type.materialtext
local.embargo.lift2028-08-01
local.embargo.terms2028-08-01
thesis.degree.departmentBaylor University. Dept. of Chemistry & Biochemistry.
thesis.degree.grantorBaylor University
thesis.degree.namePh.D.
thesis.degree.programChemistry
thesis.degree.schoolBaylor University

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