Rushing, Ann E.Hartberg, W. Keith.Ramadan, Waile.Baylor University. Dept. of Biology.2008-10-022008-10-022008-082008-10-02http://hdl.handle.net/2104/5218Includes bibliographical references (p. 60-67)This study examined the protective effects of α-lipoic acid in rats exposed to a cardiotoxic dose of the widely used chemotherapy agent doxorubicin. α-Lipoic acid significantly enhanced the survival of rats exposed to a lethal dose of doxorubicin (p<0.001). Morbidity was proportionally higher in rats treated with doxorubicin alone in contrast to rats treated with both doxorubicin and α-lipoic acid (p<0.001). Heart weights of rats treated with both α-lipoic acid and doxorubicin were similar to that of control rats, and controlling for whole body weight yielded similar results (p<0.001). α-Lipoic acid significantly reduced the cardiac microscopic damage caused by doxorubicin in rats (p<0.001). Representative micrographs supported a high degree of ultrastructural preservation in doxorubicin treated rats upon concomitant treatment with α-lipoic acid. The conclusion of this study is that α-lipoic acid is effective in protecting rats from doxorubicin induced cardiotoxicity.vi, 67 p. : ill.1142649 bytes2204975 bytesapplication/pdfapplication/pdfen-USBaylor University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact librarywebmaster@baylor.edu for inquiries about permission.Doxorubicin -- Side effects -- Prevention.Lipoic acid -- Physiological effect.Heart -- Effect of drugs on.Rats -- Physiology.Cancer -- Chemotherapy -- Complications.Drugs -- Structure-activity relationships.ThesisWorldwide access