Kim, Sung-Kun, 1968-Hermann, Megan2013-05-242013-05-2420132013-05-24http://hdl.handle.net/2104/8660Antibiotic resistance is a growing problem among many strains of bacteria, especially within the populations that most commonly infect hospital patients. A variety of molecules have been found that are capable of inhibiting the enzymes responsible for conveying resistance in a number of bacterial strains, yet inhibition among certain strains of bacteria remains elusive. This study focuses on the inhibition of the metallo-β- lactamase enzyme found in Bascillus anthracis by novel hydroxamic acid-containing molecules and G-quadruplex-based DNA aptamers. These molecules proved to be potent inhibiting molecules and therefore present a promising avenue for further research to combat antibiotic resistance in bacteria.en-USBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.Metallo-beta-lactamase.Inhibition.Bla2.Aptamer.Anthrax.Bascillus anthracis.G-quadruplex.Q-quad.Hydroxamic acid.Hydroxamate.Nosocomial infection.Antibiotic resistance.ThesisWorldwide access.Access changed 8/25/15.