Min, Jung HyunLe, Jennifer2020-05-292020-05-2920202020-05-29https://hdl.handle.net/2104/10931The xeroderma pigmentosum C (XPC) protein complex recognizes various types of environmentally induced DNA damage from the genome to initiate the nucleotide excision repair (NER) process in eukaryotes. In this study, (1) I compiled a list of missense mutations/variations in the human XPC gene that are linked to diseases (e.g., cancer) or impair its functions in vitro, from three public databases and 13 research papers. (2) I have made a homology-directed 3D structural model of human XPC protein based on existing yeast Rad4 structures; and (3) I mapped the compiled mutations onto the homology model. This work provides an important starting point to understand the impact of the various mutations in the function of the XPC protein.en-USBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.ThesisWorldwide accessAccess changed 8/24/22