Vichaya, ElisabethMcCready, RileyBaylor University2023-05-222023-05-2220232023-05-22https://hdl.handle.net/2104/12166Among chronically ill populations, affective disorders remain underdiagnosed and undertreated. A high degree of comorbidity exists between diabetes and affective disorders, particularly depression and anxiety. While the mechanisms contributing to stress-induced affective dysregulation are currently being parsed out, a direct comparison between stress-induced and hyperglycemia-induced affective dysregulation would provide insight into more effective treatments for diabetic patients suffering from depression/anxiety. The present study was performed in order to explore the effects of chronic stress and hyperglycemia in a preclinical model. We observed distinct neuroinflammatory and behavioral profiles in response to chronic stress and chronic hyperglycemia. STZ-induced hyperglycemia was associated with increased depressive-like behavior, elevations in hippocampal Bdnf and Tnf-α expression, and elevations in prefrontal cortex Il-1β expression. Chronic stress produced alterations in anxiety-like behavior and decreased prefrontal cortex Il-1β expression. While chronic stress and hyperglycemia can individually produce affective dysregulation, their combination exacerbates the symptom burden and is indicative of distinct neurobiological mechanisms.en-USBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.Diabetes.Chronic stress.ThesisNo access - Contact librarywebmaster@baylor.edu