Kane, Robert R.Nguyen, Harold H.2020-05-202020-05-202020-04-292020-05-20https://hdl.handle.net/2104/10861TAK-242 (resatorvid) is a selective antagonist of Toll-like receptor 4 (TLR4) signaling, previously shown to improve transplantation outcomes in a murine model. To further expand the structure-activity relationship of TAK-242, we have synthesized a few analogs of TAK-242. Our approach was to start with a nitrile group in place of the ester to use as a functional handle. These new molecules contain different electron-withdrawing groups on the cyclohexene ring, synthesized from a starting nitrile. This thesis also discusses syntheses of analogs of gemfibrozil, an sGC agonist. To develop a better structure-activity relationship of sGC activators, the aromatic region and carboxylic acid were targeted. The new molecules synthesized are pending biological testing for respective TLR4 inhibition and sGC activation.en-USBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.ThesisWorldwide accessAccess changed 8/24/22