The effect of hypoxia on the cytotoxicity of diesel exhaust particles and a novel oxygenating therapeutic in four cell lines.

Simple item page
dc.contributor.advisorBruce, Erica Dawn.
dc.creatorDabi, Amjad, 1990-
dc.date.accessioned2020-11-05T15:02:54Z
dc.date.available2020-11-05T15:02:54Z
dc.date.created2020-08
dc.date.issued2020-07-21
dc.date.submittedAugust 2020
dc.date.updated2020-11-05T15:02:54Z
dc.description.abstractHypoxia is characterized by oxygen levels in tissue below 2% and is implicated in many diseases and adverse health outcomes including chronic lung disease, neurodegenerative diseases, and delayed wound-healing. Many solutions for tackling hypoxia to alleviate such conditions have been proposed but all carry significant limitations. This study attempts to characterize a novel oxygenating therapeutic known as Ox66™. Another major human health concern is diesel exhaust particles (DEP), a prominent component of air pollution. This study evaluates the toxicity of DEP, Ox66™, and a mixture of both during both hypoxia and normoxia and in 24- and 48-hour exposures using four cell lines. The effect of hypoxia on cytotoxicity carries implications for the health risk assessment of air pollution in patients suffering from hypoxia-related diseases. Additionally, the effect of Ox66™ on the hypoxia induced changes in DEP exposures as observed in their mixture may provide clues about its efficacy.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttps://hdl.handle.net/2104/11097
dc.language.isoen
dc.rights.accessrightsWorldwide access.
dc.rights.accessrightsAccess changed 1/12/23.
dc.subjectHypoxia. Cytotoxicity. Diesel exhaust particles.
dc.titleThe effect of hypoxia on the cytotoxicity of diesel exhaust particles and a novel oxygenating therapeutic in four cell lines.
dc.typeThesis
dc.type.materialtext
local.embargo.lift2022-08-01
local.embargo.terms2022-08-01
thesis.degree.departmentBaylor University. Dept. of Environmental Science.
thesis.degree.grantorBaylor University
thesis.degree.levelMasters
thesis.degree.nameM.S.

Files

Original bundle

Now showing 1 - 2 of 2
Thumbnail Image
Name:
DABI-THESIS-2020.pdf
Size:
3.07 MB
Format:
Adobe Portable Document Format
Download
No Thumbnail Available
Name:
Amhad_Dabi_CopyrightAvailabilityForm.pdf
Size:
187.02 KB
Format:
Adobe Portable Document Format
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
LICENSE.txt
Size:
1.95 KB
Format:
Plain Text
Description:
Download

Collections

Electronic Theses and Dissertations
Theses/Dissertations - Environmental Science