Metabolism and Pharmacodynamic Effects of Myristicin

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dc.contributor.advisorMcGrath, Thomas
dc.contributor.authorNguyen, Vy
dc.contributor.departmentUniversity Scholars.en_US
dc.contributor.otherBaylor Universityen_US
dc.contributor.schoolsHonors College - Honors Programen_US
dc.date.accessioned2022-05-20T18:36:59Z
dc.date.available2022-05-20T18:36:59Z
dc.date.copyright2022
dc.date.issued2022-05-20
dc.description.abstractFood chemistry is a branch of science that studies the effects of food and spices on the human body. Nutmeg, a spice most commonly found in desserts and ethnic foods, contains myristicin, a compound that had been studied extensively and found to alter the body’s physiology. In this Thesis, the properties, pharmacodynamic effects, metabolism, and potential therapeutic uses of myristicin were investigated and consolidated. Beyond enhancing the flavor of food, myristicin can reduce inflammation by non-selectively inhibiting cyclooxygenase-2 (COX-2), prevent the proliferation of tumor cells by increasing the rate of apoptosis, and decrease oxidative stress by inhibiting the production of radical oxygen species. On the other hand, myristicin can negatively affect the nervous system if an overdose occurs. When a large amount of myristicin is consumed, it can transform into an amphetamine derivative, adopt the conformation of lysergic acid diethylamide (LSD), and cause the user to experience strong hallucinations and symptoms of psychosis. However, despite the adverse side effects, further research should be done into this seemingly innocuous spice to potentially translate these findings into therapeutics for diseases such as cancer, arthritis, and diabetes.en_US
dc.identifier.urihttps://hdl.handle.net/2104/11862
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsWorldwide accessen_US
dc.subjectFood chemistry.en_US
dc.subjectNutmeg.en_US
dc.subjectMyristicin.en_US
dc.titleMetabolism and Pharmacodynamic Effects of Myristicinen_US
dc.typeThesisen_US

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