The protective effect of α-lipoic acid in doxorubicin induced cardiotoxicity in rats.

Simple item page
dc.contributor.advisorRushing, Ann E.
dc.contributor.advisorHartberg, W. Keith.
dc.contributor.authorRamadan, Waile.
dc.contributor.departmentBiology.en
dc.contributor.otherBaylor University. Dept. of Biology.en
dc.date.accessioned2008-10-02T18:36:01Z
dc.date.available2008-10-02T18:36:01Z
dc.date.copyright2008-08
dc.date.issued2008-10-02T18:36:01Z
dc.descriptionIncludes bibliographical references (p. 60-67)en
dc.description.abstractThis study examined the protective effects of α-lipoic acid in rats exposed to a cardiotoxic dose of the widely used chemotherapy agent doxorubicin. α-Lipoic acid significantly enhanced the survival of rats exposed to a lethal dose of doxorubicin (p<0.001). Morbidity was proportionally higher in rats treated with doxorubicin alone in contrast to rats treated with both doxorubicin and α-lipoic acid (p<0.001). Heart weights of rats treated with both α-lipoic acid and doxorubicin were similar to that of control rats, and controlling for whole body weight yielded similar results (p<0.001). α-Lipoic acid significantly reduced the cardiac microscopic damage caused by doxorubicin in rats (p<0.001). Representative micrographs supported a high degree of ultrastructural preservation in doxorubicin treated rats upon concomitant treatment with α-lipoic acid. The conclusion of this study is that α-lipoic acid is effective in protecting rats from doxorubicin induced cardiotoxicity.en
dc.description.degreeM.S.en
dc.description.statementofresponsibilityby Waile Ramadan.en
dc.format.extentvi, 67 p. : ill.en
dc.format.extent1142649 bytes
dc.format.extent2204975 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/2104/5218
dc.language.isoen_USen
dc.rightsBaylor University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact librarywebmaster@baylor.edu for inquiries about permission.en
dc.rights.accessrightsWorldwide accessen
dc.subjectDoxorubicin -- Side effects -- Prevention.en
dc.subjectLipoic acid -- Physiological effect.en
dc.subjectHeart -- Effect of drugs on.en
dc.subjectRats -- Physiology.en
dc.subjectCancer -- Chemotherapy -- Complications.en
dc.subjectDrugs -- Structure-activity relationships.en
dc.titleThe protective effect of α-lipoic acid in doxorubicin induced cardiotoxicity in rats.en
dc.typeThesisen

Files

Original bundle

Now showing 1 - 2 of 2
Thumbnail Image
Name:
waile_ramadan_masters.pdf
Size:
2.1 MB
Format:
Adobe Portable Document Format
Description:
Thesis
Download
No Thumbnail Available
Name:
waile_ramadan_permissions.pdf
Size:
1.09 MB
Format:
Adobe Portable Document Format
Description:
Permissions Form
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.96 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Electronic Theses and Dissertations
Theses/Dissertations - Biology