Deletion of FMR1 results in sex-specific changes in behavior.

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dc.contributor.advisorLugo, Joaquin N.
dc.creatorNolan, Suzanne O., 1991-
dc.date.accessioned2017-01-19T16:45:41Z
dc.date.available2017-01-19T16:45:41Z
dc.date.created2016-12
dc.date.issued2016-12-01
dc.date.submittedDecember 2016
dc.date.updated2017-01-19T16:45:41Z
dc.description.abstractFragile X Syndrome (FXS) is a neurodevelopmental disorder caused by excessive trinucleotide (CGG) repeats in the FMR1 gene coding for fragile x mental retardation protein (FMRP). In humans, this disorder is characterized by intellectual disability, as well as other behavioral abnormalities, such as hyperactivity and social behavior abnormalities. Mutations in the FMR1 gene are found in 2 - 6 % of individuals with Autism Spectrum Disorder (ASD), making it the single largest genetic contributor to ASD. Mouse models of FXS disorder are commonly touted as preferred models for understanding ASD. Furthermore, few studies to date have examined the role of sex in the FMR1 phenotype. In the present study, we used a systemic FMR1 knockout in an FVB background strain. We examined the effects of this genetic mutation in males and females homozygous for an FMR1 mutation on measures sociability, repetitive behaviors, vocalization patterns, anxiety and fear-related learning.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/2104/9894
dc.language.isoen
dc.rights.accessrightsWorldwide access.
dc.rights.accessrightsAccess changed 6/7/19.
dc.subjectFragile X Syndrome. Autism Spectrum Disorder.
dc.titleDeletion of FMR1 results in sex-specific changes in behavior.
dc.typeThesis
dc.type.materialtext
local.embargo.lift2018-12-01
local.embargo.terms2018-12-01
thesis.degree.departmentBaylor University. Dept. of Psychology & Neuroscience.
thesis.degree.grantorBaylor University
thesis.degree.levelMasters
thesis.degree.nameM.A.

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