Molecular Correlates Of Hearing Loss: Oncomodulin And Prestin

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dc.contributor.advisorSimmons, Dwayne
dc.contributor.authorSimpson, Preston
dc.contributor.departmentBiology.en_US
dc.contributor.otherBaylor University.en_US
dc.contributor.schoolshonors collegeen_US
dc.date.accessioned2020-05-21T12:54:01Z
dc.date.available2020-05-21T12:54:01Z
dc.date.copyright2020
dc.date.issued2020-05-21
dc.description.abstractThe exquisite hearing sensitivity of mammalian hearing is due to cochlear outer hair cells (OHCs) that amplify sound signals through changes in cell membrane potential and cell length. The OHC motor protein, prestin, is responsible for this phenomenon. Oncomodulin (OCM) is the dominant calcium-binding protein in OHCs and therefore plays a major role in calcium homeostasis. Adult Ocm knockout (KO) mice are deaf and prestin expression is abnormally distributed. Since prestin and OCM are localized in the periphery of OHCs, we hypothesized that they may interact. We performed high- resolution confocal imaging in adult wildtype (WT) mice at various ages. Measures of labeling intensity found OCM and prestin labeling in OHCs colocalized. Since prestin is expressed in Ocm-KO mice, we hypothesized that increasing prestin expression might delay hearing loss in Ocm-KO mice. Previous studies show that long-term administration of nonsteroidal anti-inflammatory drugs increases prestin protein expression, OHC electromotility and improved hearing. We performed salicylate injections in Ocm-KO mice to potentially delay hearing loss. Although we found that salicylate had an effect in WT mice, there was no or little effect in Ocm-KO mice. Taken together, our results suggest that the loss of OCM may have deleterious effects on prestin function in OHCs.en_US
dc.identifier.urihttps://hdl.handle.net/2104/10874
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsWorldwide accessen_US
dc.subjectHearing Loss.en_US
dc.subjectNeurobiology.en_US
dc.subjectOncomodulin.en_US
dc.subjectPrestin.en_US
dc.subjectSalicylate.en_US
dc.titleMolecular Correlates Of Hearing Loss: Oncomodulin And Prestinen_US
dc.typeThesisen_US

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