FK506 and Rapamycin Bioconjugation: A Proposal to Increase the Viability of Transplanted Pancreatic Islets

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dc.contributor.advisorKane, Robert R.
dc.contributor.authorSells, Chloe
dc.contributor.departmentChemistry.en_US
dc.contributor.schoolsHonors College.en_US
dc.date.accessioned2017-05-23T20:15:55Z
dc.date.available2017-05-23T20:15:55Z
dc.date.copyright2017
dc.date.issued2017-05-23
dc.description.abstractType 1 Diabetes Mellitus is a widespread disease stemming from the improper functioning of pancreatic islets’ ß-cells which produce insulin, a sugar regulatory hormone. There is currently no cure. If the patient has received an islet transplant, damaging blood-mediated inflammatory responses (IBMIR) can ensue, and in addition frequent dosages of immunosuppressants that ultimately can cause chronic health issues are required. Even with immunosuppression therapy, IBMIR and other immune responses result in the destruction of many of the transplanted islets. Attempts to remediate these problems have been made in the form of surface modifications of the transplanted islets. The following thesis proposes a new method to increase the viability of transplanted pancreatic islets-- modification via esterification of the immunosuppressant drugs, specifically FK506 and Rapamycin, for immobilization followed by slow release by a ß-eliminative linker which results in an introduction of the uninhibited version of the immunosuppressant molecule into a localized area.en_US
dc.identifier.urihttp://hdl.handle.net/2104/9942
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsWorldwide access.en_US
dc.rights.accessrightsAccess changed 8/20/19.
dc.titleFK506 and Rapamycin Bioconjugation: A Proposal to Increase the Viability of Transplanted Pancreatic Isletsen_US
dc.typeThesisen_US

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