The role of hyperpolarization-activated non-selective cation current in amygdala excitability and serotonin mediated effects.

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dc.contributor.advisorKeele, N. Bradley.
dc.contributor.authorHerman, David Hans.
dc.contributor.departmentPsychology and Neuroscience.en
dc.contributor.otherBaylor University. Dept. of Psychology and Neuroscience.en
dc.date.accessioned2007-12-04T19:52:48Z
dc.date.available2007-12-04T19:52:48Z
dc.date.copyright2007
dc.date.issued2007-12-04T19:52:48Z
dc.descriptionIncludes bibliographical references (p. 43-52).en
dc.description.abstractThe hyperpolarization-activated, cyclic nucleotide-dependent non-selective cationic (HCN) current (Ih) has an important functional role in the rat brain, participating in network oscillations, temporal summation of synaptic inputs, and seizure development. Since hyperexcitability of the amygdala is related to anxiety and stress disorders, we investigated the role of Ih in amgydala excitability. In lateral amygdala (LA) pyramidal neurons, blockade of Ih reduced the degree of spiking accommodation, suggesting that Ih modulates amygdala excitability. Since serotonin (5-HT) has a significant role in fear and anxiety disorders, we additionally investigated the modulatory effect of 5-HT on Ih in LA neurons. The results show that 5-HT can reduce Ih¬, possibly through activation of 5-HT2 receptors. Overall, the results suggest that Ih may be an important new target for pharmacological treatment of psychiatric disorders involving the amygdala.en
dc.description.degreeM.A.en
dc.description.statementofresponsibilityby David Hans Herman.en
dc.format.extentix, 52 p. : ill.en
dc.format.extent148432 bytes
dc.format.extent897172 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/2104/5098
dc.language.isoen_USen
dc.rightsBaylor University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact librarywebmaster@baylor.edu for inquiries about permission.en
dc.rights.accessrightsBaylor University access onlyen
dc.subjectAmygdaloid body.en
dc.subjectSerotonin -- Physiological effect.en
dc.titleThe role of hyperpolarization-activated non-selective cation current in amygdala excitability and serotonin mediated effects.en
dc.typeThesisen

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