The Effects of Chemotherapy on Affect and Behavior in Mice
Chemotherapy has been shown to disrupt cognition in breast cancer patients, referred to as chemotherapy-induced cognitive impairment (CICI). CICI may be caused by inflammatory cytokines or decreased hippocampal neurogenesis as a result of chemotherapy toxicity, but exercise has been shown to be successful in reducing these effects. CICI is also accompanied by affective disruption, but has not been as extensively studied. This study uses behavioral tests to examine the effects of chemotherapy and exercise on anxiety-like and depressive-like behaviors in mice. The results indicate that chemotherapy causes affective disturbance in mice, meaning that it may be causing anxiety and depression in breast cancer patients. The results also show that exercise may be preventative against breast cancer patients developing anxiety and depression.