Vasopressin decreases excitability in rat lateral amygdala neurons through inhibition of hyperpolarization-activated cationic current.

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dc.contributor.advisorKeele, N. Bradley.
dc.contributor.authorBlakeley, Hillary Joy.
dc.contributor.departmentPsychology and Neuroscience.en
dc.contributor.otherBaylor University. Dept. of Psychology and Neuroscience.en
dc.date.accessioned2011-05-13T12:27:40Z
dc.date.available2011-05-13T12:27:40Z
dc.date.copyright2011-05
dc.date.issued2011-05-13T12:27:40Z
dc.description.abstractThe amygdala is a critical part of the limbic system with important roles in social behavior. Abnormal activity in the lateral amygdala nucleus (LA) has been implicated in several disorders, including autism spectrum disorder (ASD) in which abnormal social functioning is a primary symptom. The peptide hormones arginine-vasopressin (AVP) and oxytocin (OT) are strongly implicated in social behavior, and may also be involved in the pathophysiology of ASD. Here, we show that AVP causes an increase in excitability, through eliciting a decrease in action potential accommodation and hyperpolarization-activated current (Ih) amplitude in LA pyramidal cells. OT exerts complementary effects, causing an increase in action potential accommodation and Ih amplitude, resulting in decreased excitability. These results suggest AVP and OT may modulate social behavior by controlling excitability in the amygdala.en
dc.description.degreePh.D.en
dc.description.statementofresponsibilityby Hillary Joy Blakeley.en
dc.format.extent76106 bytes
dc.format.extent1745544 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/2104/8182
dc.language.isoen_USen
dc.rightsBaylor University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact librarywebmaster@baylor.edu for inquiries about permission.en
dc.rights.accessrightsWorldwide accessen
dc.subjectAmygdala.en
dc.subjectExcitability.en
dc.subjectVasopressin.en
dc.subjectOxytocin.en
dc.subjectH-current.en
dc.titleVasopressin decreases excitability in rat lateral amygdala neurons through inhibition of hyperpolarization-activated cationic current.en
dc.typeThesisen

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