Interaction between cell adhesion molecules and stress hormones following different intensities of cycling exercise in obese males.
| dc.contributor.advisor | Koh, Yunsuk. | |
| dc.creator | Park, Jinkyung, 1985- | |
| dc.date.accessioned | 2016-09-01T13:28:01Z | |
| dc.date.available | 2016-09-01T13:28:01Z | |
| dc.date.created | 2016-08 | |
| dc.date.issued | 2016-08-03 | |
| dc.date.submitted | August 2016 | |
| dc.date.updated | 2016-09-01T13:28:01Z | |
| dc.description.abstract | The purpose of the current study was to examine the interaction between exercise-induced stress hormones [epinephrine (E), norepinephrine (NE), and cortisol (COR)] and soluble cell adhesion molecules [soluble intercellular adhesion molecule 1(sICAM-1), soluble vascular cell adhesion molecule 1(sVCAM-1), and soluble endothelial selectin (sE-selectin)] over 24 hours following different intensities of exercise in obese men. In a randomised, cross-over design, 15 physically inactive (physical activity < 2 days per week) obese (BMI > 30 kg/m²) men between the ages of 18-30 years performed a single bout of cycling exercise (average energy expenditure ~ 300 kcal) at two different intensities [low-intensity (LI): 50% of maximal heart rate and higher-intensity (HI): 80% of maximal heart rate] in random order. Overnight fasting blood samples were collected at baseline, immediately post-exercise (IPE), 1-hr PE, and 24-hr PE. All data were analyzed using an analysis of variance with repeated measures, along with Bonferroni multiple comparisons. A linear regression analysis was used to examine the interaction between exercise-induced stress hormones and soluble cell adhesion molecules (sCAMs) (p < .05), sICAM-1, sVCAM-1, E or NE did not change, while sE-selectin at 1-hr PE (10.25±1.07 ng/mL) significantly decreased (p = .045) from baseline (12.22±1.39 ng/mL). COR at IPE (262.12±31.09 ng/ml) was significantly higher (p = .001) than 1-hr PE (189.35±31.11 ng/ml) during HI. In contrast, COR at IPE (187.52±31.09 ng/ml, p = .009) and 1-hr PE (156.24±31.11 ng/ml, p = .001) was significantly lower than baseline (259.75±23.07 ng/ml) during LI. COR and sICAM-1 had a negative relationship at 1-hr PE during LI (r² = .34, p = .02), whereas COR and sVCAM-1 had a positive relationship at IPE during HI (r² = .36, p = .02). Additionally, there was a positive relationship between E and sE-selectin at 1-hr PE during HI (r² = .56, p = .01), and a negative relationship between COR and sE-selectin at baseline during LI and HI (r² = .32, p = .03 and r² = .70, p < .001, respectively). An exercise-induced decrease in sE-selectin observed in the current study suggests sE-selectin may be an early marker of exercise-induced immunosuppression due to epinephrine. Although sICAM-1 and sVCAM-1 did not significantly change following exercise, a significant interaction between COR and sICAM-1 and sVCAM-1 suggests COR may play a critical role in the modulation of sICAM-1 and sVCAM-1. | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.uri | http://hdl.handle.net/2104/9809 | |
| dc.language.iso | en | |
| dc.rights.accessrights | Worldwide access. | |
| dc.rights.accessrights | Access changed 12/15/21. | |
| dc.subject | Stress hormone. Cell adhesion molecule. Exercise. | |
| dc.title | Interaction between cell adhesion molecules and stress hormones following different intensities of cycling exercise in obese males. | |
| dc.type | Thesis | |
| dc.type.material | text | |
| local.embargo.lift | 2021-08-01 | |
| local.embargo.terms | 2021-08-01 | |
| thesis.degree.department | Baylor University. Dept. of Health, Human Performance & Recreation. | |
| thesis.degree.grantor | Baylor University | |
| thesis.degree.level | Doctoral | |
| thesis.degree.name | Ph.D. |
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