Copper ionophores induce autophagy in melanoma cells.

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dc.contributor.advisorFarmer, Patrick Joseph, 1957-
dc.contributor.authorDao, Long, 1988-
dc.contributor.departmentChemistry and Biochemistry.en_US
dc.contributor.schoolsBaylor University. Dept. of Chemistry and Biochemistry.en_US
dc.date.accessioned2013-09-16T12:59:17Z
dc.date.available2013-09-16T12:59:17Z
dc.date.copyright2013-05
dc.date.issued2013-09-16
dc.description.abstractMalignant melanoma is a particularly aggressive form of skin cancer, for which the only current treatment option is excision. As melanoma is an inherently antiapoptotic model of cancer, other avenues of cell death were pursued, namely autophagy, a mechanism in which a cell devours itself in times of stress. In this study, two copper ionophores, disulfiram and thiomaltol, were investigated against melanoma. By using immunocytochemistry, Western Blotting and supravital staining, it was confirmed that both ionophores induce autophagy, and furthermore, drive the process to completion. In addition, when tested for viability with the autophagy inhibitor hydroxychloroquine, both ionophores showed evidence of synergism. To further study the migration of copper, STEM-EDX was used on thiomaltol treated melanoma cells.en_US
dc.description.degreeM.S.en_US
dc.identifier.urihttp://hdl.handle.net/2104/8738
dc.language.isoen_USen_US
dc.publisheren
dc.rightsBaylor University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact librarywebmaster@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsWorldwide access.en_US
dc.rights.accessrightsAccess changed 8/26/15.
dc.subjectCopper ionophores.en_US
dc.subjectAutophagy.en_US
dc.subjectMelanoma.en_US
dc.subjectDisulfiram.en_US
dc.subjectThiomaltol.en_US
dc.titleCopper ionophores induce autophagy in melanoma cells.en_US
dc.typeThesisen_US

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