The Synthesis of New Pyrylium and Pyridinium Salts

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dc.contributor.advisorGarner, Charles M. (Charles Manley), 1957-
dc.contributor.authorKorbitz, Holland
dc.contributor.departmentBiochemistry.en_US
dc.contributor.schoolsHonors College.en_US
dc.date.accessioned2013-05-23T23:44:31Z
dc.date.available2013-05-23T23:44:31Z
dc.date.copyright2012
dc.date.issued2013-05-23
dc.description.abstractThe synthesis, properties, and applications of symmetrical and unsymmetrical pyrylium and pyridinium salts is investigated. Our group has found particular interest in chiral pyrylium salts due to the fact that they are almost unknown in the literature. We have applied the reaction of acyl chlorides with tert-butanol to the preparation of new pyrylium tetrafluoroborate salts. Some of these pyrylium salt derivatives form diastereomers when prepared. Moreover, they are favorable to study epimerization at the alpha centers. The ease of epimerization at pyrylium chiral centers has not been studied previously. We also applied the reaction of acyl chlorides with dypnone to form asymmetrical pyrylium salts. Our group has also found interest in positively charged pyridinium salts, which provide a route for the possible improvement on the bioavailability of hydrophobic compounds and also an interesting interaction with different substrates. We optimized reaction conditions for reacting substituted pyrylium salts with primary amines to obtain pyridinium salts. Future work will be directed towards obtaining pyridinium salts from primary amines with known biological activity. The objective of this study is to synthesize new pyrylium and pyridinium salts.en_US
dc.identifier.urihttp://hdl.handle.net/2104/8628
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsWorldwide accessen_US
dc.subjectPyrylium salts.en_US
dc.subjectPyridinium salts.en_US
dc.titleThe Synthesis of New Pyrylium and Pyridinium Saltsen_US
dc.typeThesisen_US

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