Regulation of Anxiety and Alcohol Drinking Behavior by Neuropeptide Y and Corticotropin-Releasing Hormone in the Central Nucleus of the Amygdala

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dc.contributor.advisorKeele, N. Bradley.
dc.contributor.authorPeña, Adrian I.
dc.contributor.departmentPsychology and Neuroscience.en_US
dc.contributor.otherBaylor University.en_US
dc.contributor.schoolsHonors College.en_US
dc.date.accessioned2012-05-07T20:03:52Z
dc.date.available2012-05-07T20:03:52Z
dc.date.copyright2012-05-04
dc.date.issued2012-05-07
dc.description.abstractThe rising consumption of alcohol in Western societies and subsequent alcoholrelated life problems that develop has been labeled a major health and social issue. Finding an effective treatment for alcohol dependence has been faced with difficulty, as this is a complex phenomenon that has its roots in a variety of factors. Anxiety and stress have a strong correlation with alcohol intake behavior, and cyclic bouts of alcohol drinking and withdrawal lead to enhanced anxiety reactivity. Recently, two neuromodulators have been implicated in the regulation of anxiety and ensuing alcohol intake: neuropeptide Y (NPY) and corticotropin releasing hormone (CRH) both of which exert their effects on the central nucleus of the amygdala (CeA), a structure implicated in anxiety disorders. This review examines how these two neuromodulators interact, the cellular and molecular mechanisms by which they exert their effects, how these mechanisms affect neuronal excitability within the CeA, and how ethanol relates to both NPY and CRH which will hopefully answer questions with regards to the neurophysiology of alcohol intake behavior.en_US
dc.identifier.urihttp://hdl.handle.net/2104/8389
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsWorldwide accessen_US
dc.subjectNeuropeptide Y.en_US
dc.subjectAlcohol dependence.en_US
dc.subjectStress and anxiety.en_US
dc.subjectAmygdala hyperexcitability.en_US
dc.subjectLiterature review.en_US
dc.titleRegulation of Anxiety and Alcohol Drinking Behavior by Neuropeptide Y and Corticotropin-Releasing Hormone in the Central Nucleus of the Amygdalaen_US
dc.typeThesisen_US

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