Potential Inhibitors of Bascillus anthracis’ Metallo- β-Lactamase by Hydroxamate Functional Groups and G-Quadruplex Aptamers

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dc.contributor.advisorKim, Sung-Kun, 1968-
dc.contributor.authorHermann, Megan
dc.contributor.departmentBiochemistry.en_US
dc.contributor.schoolsHonors College.en_US
dc.date.accessioned2013-05-24T20:11:40Z
dc.date.available2013-05-24T20:11:40Z
dc.date.copyright2013
dc.date.issued2013-05-24
dc.description.abstractAntibiotic resistance is a growing problem among many strains of bacteria, especially within the populations that most commonly infect hospital patients. A variety of molecules have been found that are capable of inhibiting the enzymes responsible for conveying resistance in a number of bacterial strains, yet inhibition among certain strains of bacteria remains elusive. This study focuses on the inhibition of the metallo-β- lactamase enzyme found in Bascillus anthracis by novel hydroxamic acid-containing molecules and G-quadruplex-based DNA aptamers. These molecules proved to be potent inhibiting molecules and therefore present a promising avenue for further research to combat antibiotic resistance in bacteria.en_US
dc.identifier.urihttp://hdl.handle.net/2104/8660
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsWorldwide access.en_US
dc.rights.accessrightsAccess changed 8/25/15.
dc.subjectMetallo-beta-lactamase.en_US
dc.subjectInhibition.en_US
dc.subjectBla2.en_US
dc.subjectAptamer.en_US
dc.subjectAnthrax.en_US
dc.subjectBascillus anthracis.en_US
dc.subjectG-quadruplex.en_US
dc.subjectQ-quad.en_US
dc.subjectHydroxamic acid.en_US
dc.subjectHydroxamate.en_US
dc.subjectNosocomial infection.en_US
dc.subjectAntibiotic resistance.en_US
dc.titlePotential Inhibitors of Bascillus anthracis’ Metallo- β-Lactamase by Hydroxamate Functional Groups and G-Quadruplex Aptamersen_US
dc.typeThesisen_US

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