The Effect of Early-life Status Epilepticus on Ultrasonic Vocalizations in Mice

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dc.contributor.advisorLugo, Joaquin N.
dc.contributor.authorReynolds, Conner
dc.contributor.departmentNeuroscience.en_US
dc.contributor.schoolsHonors College.en_US
dc.date.accessioned2016-08-10T16:36:54Z
dc.date.available2016-08-10T16:36:54Z
dc.date.copyright2016
dc.date.issued2016-08-10
dc.description.abstractThe purpose of this study is to investigate the effects of kainate-induced early life seizures on vocalization behavior and intracellular signaling pathways involved in nervous system development. On postnatal day 10, male and female 129SvEvTac mice received a single intraperitoneal injection of kainic acid 2.5 mg/kg to induce 1-2 hours of status epilepticus. On postnatal days 11 and 12, mice were removed from the home cage and isolation-induced ultrasonic vocalizations (USVs) were recorded using the UltraVox software. The PI3K-Akt-mTOR and Canonical Wnt intracellular signaling pathways in the brains of pups on postnatal day 12 were investigated by western blotting analysis. There was significant suppression of USV quantity and total duration at the 50kHz frequency on postnatal day 12 following seizures. These results were both sex-specific and associated with changes in the PI3K-Akt-mTOR intracellular signaling pathway. These findings support the growing body of evidence for USV behavior as an early behavioral marker of neural deficits.en_US
dc.identifier.urihttp://hdl.handle.net/2104/9764
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsWorldwide access.en_US
dc.rights.accessrightsAccess changed 7/11/18.
dc.subjectepilepsyen_US
dc.subjectseizureen_US
dc.subjectearly lifeen_US
dc.subjectneonatalen_US
dc.subjectvocalizationen_US
dc.subjectultrasonicen_US
dc.subjectUSVen_US
dc.subjectmTORen_US
dc.subjectPI3Ken_US
dc.subjectFMRPen_US
dc.subjectBiomarkeren_US
dc.subjectpostnatalen_US
dc.titleThe Effect of Early-life Status Epilepticus on Ultrasonic Vocalizations in Miceen_US
dc.typeThesisen_US

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