The Role of the mTOR Pathway in Learning and Memory

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dc.contributor.advisorLugo, Joaquin N.
dc.contributor.authorMorrison, Jessica
dc.contributor.departmentNeuroscience.en_US
dc.contributor.otherBaylor University.en_US
dc.contributor.schoolsHonors College.en_US
dc.date.accessioned2013-05-24T20:15:08Z
dc.date.available2013-05-24T20:15:08Z
dc.date.copyright2013
dc.date.issued2013-05-24
dc.description.abstractResearch implicates the mTOR pathway, now known to be a regulator of protein synthesis, as a major player in both neuronal development and cognition. This study demonstrates, both through experimentation and a review of the literature, how disrupting the function of the mTOR pathway has adverse effects on learning and memory. Through delayed fear conditioning procedures, trace fear conditioning procedures, and a novel object test, this study demonstrates marked deficits in learning and memory in homozygous PTEN knockout mice, specifically in the Gfap-CreloxP induced knockout. This opens the door for further research on treatments with the potential to alleviate the symptoms of the knockout that may then be implemented in the treatment of hyperactive mTOR related disease.en_US
dc.identifier.urihttp://hdl.handle.net/2104/8677
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsWorldwide access.en_US
dc.rights.accessrightsAccess changed 8/25/15.
dc.subjectMTOR pathway.en_US
dc.subjectLearning and Memoryen_US
dc.subjectPTEN knockouten_US
dc.subjectSynaptic plasticityen_US
dc.titleThe Role of the mTOR Pathway in Learning and Memoryen_US
dc.typeThesisen_US

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