The Role of Directly and Indirectly Acting Compounds on Development and Oxidative Stress on Various Early Life Stages

Simple item page
dc.contributor.advisorBrooks, Bryan W.
dc.contributor.authorJo, Yoomin
dc.contributor.departmentUniversity Scholars.en_US
dc.contributor.otherBaylor University.en_US
dc.contributor.schoolsUniversity Scholars.en_US
dc.date.accessioned2018-05-21T17:05:34Z
dc.date.available2018-05-21T17:05:34Z
dc.date.copyright2018-05-10
dc.date.issued2018-05-21
dc.description.abstractRecent studies in our laboratory comparatively explored toxicity responses associated with oxidative stress (OS) pathways in fathead minnow (Pimephales promelas) and zebrafish (Danio rerio) at early life stages. However, discrepancies between responses of these two common fish models have not been fully investigated across developmental ages. The objective of this study was to examine how OS responses vary: 1. throughout development; 2. between directly acting chemicals and metabolized chemicals; 3. between fathead minnow and zebrafish. Fathead minnow and zebrafish were exposed to R-(-)-carvone or bisphenol-A (BPA). Fish were exposed to control and 40% of the 96-h LC50 value. At 24, 48, 72, and 96 hours post exposure, mortality, hatching rate, and developmental deformity were assessed. Expression of select OS associated genes was measured using qPCR. Results demonstrate that OS responses varied across development in both species, but were also different between both zebrafish and fathead minnow. Furthermore, these responses differed across development between directly acting compounds and metabolized compounds, but only for acute toxic endpoints. In future studies, it will be important to consider bioavailability and uptake in understanding whether adverse outcomes vary across developmental age and between species.en_US
dc.identifier.urihttp://hdl.handle.net/2104/10316
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsWorldwide accessen_US
dc.titleThe Role of Directly and Indirectly Acting Compounds on Development and Oxidative Stress on Various Early Life Stagesen_US
dc.typeThesisen_US

Files

Original bundle

Now showing 1 - 2 of 2
Thumbnail Image
Name:
YoominJ_HonorThesis_FINAL.pdf
Size:
797.14 KB
Format:
Adobe Portable Document Format
Description:
Main Article
Download
No Thumbnail Available
Name:
Honors Agreement_YJ.png
Size:
13.89 MB
Format:
Portable Network Graphics
Description:
Honors Thesis Copyright and Availability Form
Download

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.87 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Theses - Honors College