Compilation and Structural Analyses of Disease-linked Mutations in the Xeroderma  Pigmentosum C (XPC) DNA Repair Protein

Le, Jennifer

Compilation and Structural Analyses of Disease-linked Mutations in the Xeroderma Pigmentosum C (XPC) DNA Repair Protein

dc.contributor.advisor	Min, Jung Hyun
dc.contributor.author	Le, Jennifer
dc.contributor.department	Biochemistry.	en_US
dc.contributor.schools	honors college	en_US
dc.date.accessioned	2020-05-29T12:35:53Z
dc.date.available	2020-05-29T12:35:53Z
dc.date.copyright	2020
dc.date.issued	2020-05-29
dc.description.abstract	The xeroderma pigmentosum C (XPC) protein complex recognizes various types of environmentally induced DNA damage from the genome to initiate the nucleotide excision repair (NER) process in eukaryotes. In this study, (1) I compiled a list of missense mutations/variations in the human XPC gene that are linked to diseases (e.g., cancer) or impair its functions in vitro, from three public databases and 13 research papers. (2) I have made a homology-directed 3D structural model of human XPC protein based on existing yeast Rad4 structures; and (3) I mapped the compiled mutations onto the homology model. This work provides an important starting point to understand the impact of the various mutations in the function of the XPC protein.	en_US
dc.identifier.uri	https://hdl.handle.net/2104/10931
dc.language.iso	en_US	en_US
dc.rights	Baylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.	en_US
dc.rights.accessrights	Worldwide access	en_US
dc.rights.accessrights	Access changed 8/24/22
dc.title	Compilation and Structural Analyses of Disease-linked Mutations in the Xeroderma Pigmentosum C (XPC) DNA Repair Protein	en_US
dc.type	Thesis	en_US