Vaping and Comorbidities: Designing Experiments to Establish Adverse Health Effects

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dc.contributor.advisorSayes, Christie
dc.contributor.authorDickinson, Jake
dc.contributor.departmentBiochemistry.en_US
dc.contributor.otherBaylor Universityen_US
dc.contributor.schoolsHonors College - Honors Programen_US
dc.date.accessioned2022-05-18T20:11:10Z
dc.date.available2022-05-18T20:11:10Z
dc.date.copyright2022
dc.date.issued2022-05-18
dc.description.abstractModern diseases are complex and are dangerous when occur simultaneously with another conditions. While common, this phenomenon is not described universally, and existing terms presented in the literature often having conflicting definitions. In Chapter 1, the term “comorbidity” is selected and defined as the presence of multiple conditions or diseases simultaneously in a single individual. Additionally, well-known examples of comorbidities such as asthma with allergic rhinitis and lung cancer with chronic obstructive pulmonary disease (COPD) are discussed. Vaping is currently a major health crisis in the United States. Unfortunately, the current scientific understanding on the effects of vaping is incomplete. Although there are multiple ways in which people vape, this thesis will focus on vaping through the use of e-cigarettes. Significant knowledge gaps include understanding the interactions between vaping and comorbid conditions and the induced toxicological effects or biological interactions among the individual versus mixed components of e-liquid to pulmonary cells. To make progress toward filling data gaps, Chapter 2 discusses two experiments that were conducted. The first experiment determined the LC50 value of the e-cigarette flavoring cinnamaldehyde using two different viability assays: MTS and PrestoBlue. The aim of this experiment was to select a preferred assay for viability to be used in further studies. The second experiment determined the LC50 values of two common e-cigarette flavorings, cinnamaldehyde and myrcene. This enabled a comparison of the toxicity of each ingredient and established a robust protocol for further studies. Chapter 3 discusses future work and offers a more sophisticated experimental design that will both broaden and deepen the scope of the research.en_US
dc.identifier.urihttps://hdl.handle.net/2104/11817
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsWorldwide accessen_US
dc.subjectVaping.en_US
dc.subjectComorbidities.en_US
dc.subjectElectronic-cigarettes.en_US
dc.titleVaping and Comorbidities: Designing Experiments to Establish Adverse Health Effectsen_US
dc.typeThesisen_US

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