Intermittent Ethanol-induced Fear Memory Impairment with Differential Hippocampal Activation in Male Mice

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dc.contributor.advisorLara, Hwa
dc.contributor.authorDuval-Arnould, Sean
dc.contributor.departmentNeuroscience.en_US
dc.contributor.otherBaylor University.en_US
dc.contributor.otherBaylor Universityen_US
dc.contributor.schoolsHonors College - Honors Programen_US
dc.contributor.schoolsHonors College - Honors Programen_US
dc.date.accessioned2023-05-22T18:08:24Z
dc.date.available2023-05-22T18:08:24Z
dc.date.copyright2023-05-01
dc.date.issued2023-05-22
dc.description.abstractThe limbic system, particularly the hippocampus and amygdala, are oft-studied and well-established regions for fear learning and memory and have been seen to critically underlie the encoding of contextual fear memory. Literature has shown that chronic ethanol consumption has a negative effect on hippocampal beta-dynorphin – a neuropeptide implicated in limbic LTP and fear-forming memories. The impact of self- administered chronic ethanol on hippocampal fear memory has not yet been investigated in mice. In this study, we exposed 3 cohorts of C57BL/6J mice to an intermittent-access ethanol protocol for 6 weeks followed by fear conditioning tests. We found significant differences in freezing behaviour between binge-like drinking mice and water controls on a trace conditioning protocol. Immunohistochemistry for c- Fos was performed, and significant differences were seen in CA1, CA3, and the dentate gyrus between binge-like mice and controls after fear exposure. These findings suggest that chronic ethanol consumption has a dampening effect on fear learning in mice and implicates differential hippocampal activation potentially underlying the behaviour seen.en_US
dc.identifier.urihttps://hdl.handle.net/2104/12198
dc.language.isoenen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsWorldwide accessen_US
dc.subjectNeuroscienceen_US
dc.subjectAddictionen_US
dc.subjectSubstance-use Disordersen_US
dc.subjectAlcoholen_US
dc.subjectSTEMen_US
dc.titleIntermittent Ethanol-induced Fear Memory Impairment with Differential Hippocampal Activation in Male Miceen_US
dc.typeThesisen_US

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