Kinetic Studies of Thiosemicarbazone Inhibitors of Cruzain, a Validated Target of Cruzain

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dc.contributor.advisorTrawick, Mary Lynn.
dc.contributor.authorGuillory, Joseph
dc.contributor.departmentBiology.en_US
dc.contributor.otherBaylor University.en_US
dc.contributor.schoolsHonors College.en_US
dc.date.accessioned2013-05-24T20:10:47Z
dc.date.available2013-05-24T20:10:47Z
dc.date.copyright2013-05-01
dc.date.issued2013-05-24
dc.description.abstractChagas’ disease is caused by the flagellate protozoan Trypanosoma cruzi. As determined by the World Health Organization, effective therapeutic medications are needed for the treatment of Chagas’ disease. Cruzain, a powerful cysteine protease involved in cell invasion, immune evasion, and metabolism of the T. cruzi parasite, is a validated target for the disease. A number of thiosemicarbazone derivatives are inhibitors of cruzain. In this study, the kinetic mechanism of a potent thiosemicarbazone inhibitor of cruzain was investigated. A microplate reader using a 96-well plate format was used to perform fluorometric assays. Progress curves provided evidence that this thiosemicarbazone compound is a time-dependent inhibitor of cruzain. This was a collaborative study between the Trawick and Pinney groups at Baylor University.en_US
dc.identifier.urihttp://hdl.handle.net/2104/8656
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsWorldwide access.en_US
dc.rights.accessrightsAccess changed 8/25/15.
dc.titleKinetic Studies of Thiosemicarbazone Inhibitors of Cruzain, a Validated Target of Cruzainen_US
dc.typeThesisen_US

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