Multiple Early-life Seizures Alter Neonatal Communicative Behavior in Fmr1 Knockout Mice

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dc.contributor.advisorLugo, Joaquin
dc.contributor.authorNguyen, Phuoc
dc.contributor.departmentNeuroscience.en_US
dc.date.accessioned2021-05-21T13:41:20Z
dc.date.available2021-05-21T13:41:20Z
dc.date.copyright2021
dc.date.issued2021-05-21
dc.description.abstractFragile X syndrome (FXS) is the leading monogenic cause of intellectual disability and a significant contributor to Autism spectrum disorder. In addition to autistic-like phenotypes, individuals with FXS are subject to developing numerous comorbidities, one of the most prevalent being seizures. In the present study, we investigated how FMR1 germline mutation impacts neonatal communicative behavior in the FXS mouse model, both with and without early-life seizures (ELSs). On postnatal day (PD) 7 through PD11, we administered 3 flurothyl seizures to both Fmr1 KO and wild type mice. On PD12, all pups were temporarily isolated from their home cage and USVs were recorded. Significant alterations were found in both spectral and temporal measurements across seizure groups. We found that induction of seizures across PD7–11 resulted in increased frequency of USVs produced (P < 0.05), longer duration (P < 0.05), and cumulative duration (P < 0.05) in both genotypes. Overall, this study provides evidence that magnitude of communication impairment in FXS mice is significantly impacted by seizure frequency load early in development.en_US
dc.identifier.urihttps://hdl.handle.net/2104/11330
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsWorldwide accessen_US
dc.rights.accessrightsAccess changed 9/21/23
dc.subjectEarly-life seizures.en_US
dc.subjectFragile X Syndrome.en_US
dc.subjectVocalization.en_US
dc.subjectFlurothyl.en_US
dc.subjectCritical period.en_US
dc.titleMultiple Early-life Seizures Alter Neonatal Communicative Behavior in Fmr1 Knockout Miceen_US
dc.typeThesisen_US

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