CRISPR: Its Origins, Function and Future

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dc.contributor.advisorTrakselis, Michael
dc.contributor.authorBhatia, Priyankaa
dc.contributor.departmentBiochemistry.en_US
dc.contributor.otherBaylor University.en_US
dc.contributor.schoolsHonors College.en_US
dc.date.accessioned2017-05-04T19:17:56Z
dc.date.available2017-05-04T19:17:56Z
dc.date.copyright2017-05-02
dc.date.issued2017-05-04
dc.description.abstractWhat started as simply an observation of a confusing set of tandem palindromic repeats in bacterial genomes grew into the discovery and harnessing of the CRISPR-Cas9 mechanism of gene editing.  Clustered regularly interspaced short palindromic repeats (CRISPR) are a naturally occurring adaptive immune system present in microbes. They direct foreign DNA cleavage by storing DNA sequences from the foreign invaders and then using those sequences in a protein effector complex to bring about double stranded breaks. They are mainly used against bacteriophages. Once this mechanism was discovered and studied in its various forms, it was found that the Cas9 complex could be used in other organisms and could be engineered to target specific DNA sequences. This opened the floodgates for research into the gene editing properties of CRISPR-Cas9 and its application to therapeutic genetics as well as drug research.  The perfection of the technology brought along with it a long running patent battle between two labs for the rights to the technology as well as a constant emergence of new research showing the benefits, possibilities and problems CRISPR-based editing brings to light.en_US
dc.identifier.urihttp://hdl.handle.net/2104/9928
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsNo access - Contact librarywebmaster@baylor.eduen_US
dc.subjectBiochemistryen_US
dc.subjectGeneticsen_US
dc.titleCRISPR: Its Origins, Function and Futureen_US
dc.typeThesisen_US

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