Chemical toxicity distributions in aquatic toxicology : relative sensitivities of estrogenicity assays and ecotoxicity of parabens in model freshwater organisms.

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dc.contributor.advisorBrooks, Bryan W.
dc.contributor.authorDobbins, Laura L.
dc.contributor.departmentBiology.en
dc.contributor.otherBaylor University. Dept. of Biology.en
dc.date.accessioned2009-07-01T17:00:35Z
dc.date.available2009-07-01T17:00:35Z
dc.date.copyright2009-05
dc.date.issued2008-12
dc.descriptionIncludes bibliographical references (p. 66-76).en
dc.description.abstractA probabilistic ecological hazard assessment technique, chemical toxicity distributions, was used to examine the relative sensitivities of in vitro and in vivo assays for detecting estrogenicity, and to assess the hazards associated with parabens to model aquatic organisms, Pimephales promelas and Daphnia magna. Parabens represent a class of understudied personal care products with estrogenic activity that have been detected in surface waters. MCF-7 and rainbow trout vitellogenin induction were found to be the most sensitive in vitro and in vivo assays of estrogenicity, respectively. Parabens were determined to not pose a hazard to aquatic organisms at levels that are environmentally relevant, based on the bioassay endpoints evaluated. A screening level assessment further identified estrogenic activity of select parabens to adult male P. promelas. This thesis demonstrated the utility of chemical toxicity distributions for determining sensitivities among toxicological models and for assessing those compounds for which environmental exposure data are limited.en
dc.description.degreeM.S.en
dc.description.statementofresponsibilityby Laura L. Dobbins.en
dc.format.extentxi, 76 p. : ill.en
dc.format.extent217294 bytes
dc.format.extent277790 bytes
dc.format.extent850518 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.identifier.citationDobbins, Laura L., Richard A. Brain, and Bryan W. Brooks. "Comparison of the sensitivities of common in vitro and in vivo assays of estrogenic activity : application of chemical toxicity distributions." Environmental Toxicology and Chemistry 27, no. 12 (2008): 2608-2616.en
dc.identifier.urihttp://hdl.handle.net/2104/5350
dc.language.isoen_USen
dc.rightsBaylor University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact librarywebmaster@baylor.edu for inquiries about permission.en
dc.rights.accessrightsBaylor University access onlyen
dc.subjectEcological risk assessment.en
dc.subjectWater quality bioassay.en
dc.subjectFresh water organisms -- Effect of water pollution on.en
dc.subjectEstrogen -- Environmental aspects.en
dc.subjectEstrogen -- Toxicity testing -- In vitro.en
dc.subjectEstrogen -- Toxicity testing -- In vivo.en
dc.subjectWater -- Pollution -- Toxicology.en
dc.titleChemical toxicity distributions in aquatic toxicology : relative sensitivities of estrogenicity assays and ecotoxicity of parabens in model freshwater organisms.en
dc.typeThesisen

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