Investigating the efficacy of a novel therapeutic to mitigate traumatic brain injury : contributions of environmental exposures to overall healing.

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dc.contributor.advisorBruce, Erica Dawn.
dc.creatorYang, Peijin, 1987-
dc.date.accessioned2015-09-04T13:40:34Z
dc.date.available2015-09-04T13:40:34Z
dc.date.created2015-08
dc.date.issued2015-07-30
dc.date.submittedAugust 2015
dc.date.updated2015-09-04T13:40:34Z
dc.description.abstractTraumatic brain injury (TBI) is a leading cause of disability and premature death among both civilians and military. Morbidity and deaths are mainly caused by several secondary process that exacerbate brain dysfunction in the minutes to days following the primary injury when blood vessels and tissues are torn, stretched, or compressed. In previous studies, proper oxygen supply has been shown to help brain cells to grow and repair, remove the obstruction in blood flow, and alleviate brain edema to prevent secondary injury. OX-66, a novel therapeutic, potentially provides an efficient supply of oxygen to the cells. This therapeutic was investigated in this study to determine its cytotoxicity and potential mechanism of cellular repair in invitro-injured rat brain cells. The effects of exposure to polycyclic aromatic hydrocarbons (PAH) on TBI patients and the corresponding restorative influence of OX-66 were also evaluated.
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/2104/9466
dc.language.isoen
dc.rights.accessrightsWorldwide access
dc.rights.accessrightsAccess changed 12/5/17
dc.subjectTraumatic brain injury. Novel therapeutic.
dc.titleInvestigating the efficacy of a novel therapeutic to mitigate traumatic brain injury : contributions of environmental exposures to overall healing.
dc.typeThesis
dc.type.materialtext
local.embargo.lift2017-08-01
local.embargo.terms2017-08-01
thesis.degree.departmentBaylor University. Dept. of Environmental Science.
thesis.degree.grantorBaylor University
thesis.degree.levelMasters
thesis.degree.nameM.S.

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