Sample size determination for two sample binomial and Poisson data models based on Bayesian decision theory.




Sides, Ryan A.

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Sample size determination continues to be an important research area in statistical analysis due to the cost and time constraints that often exist in areas such as pharmaceuticals and public health. We begin by outlining the work of a previous article that attempted to find a minimum necessary sample size in order to reach a desired expected power for binomial data under the Bayesian paradigm. We make improvements to their efforts that allow us to specify not only a desired expected Bayesian power, but also a more generic loss function and a desired expected Bayesian significance level, the latter having never been considered previously. We then extend these methodologies to handle Poisson data and discuss challenges in the methodology. We cover a detailed example in both cases and display various results of interest.

We conclude by covering a mixed treatment comparisons meta-analysis problem when analyzing Poisson data. Traditional methods do not allow for the presence of underreporting. Here, we illustrate how a constant underreporting rate for all treatments has no effect on relative risk comparisons; however, when this rate changes per treatment, not accounting for it can lead to serious errors. Our method allows this to be taken into account so that correct analyses can be made.



Bayesian sample size determination., Binomial sample size determination., Poisson sample size determination., Expected Bayesian power., Expected Bayesian significance level., Mixed treatment comparisons meta-analysis., Indirect comparisons., Underreporting in Poisson data models.