The effects of creatine monohydrate supplementation on creatine transporter activity and creatine metabolism in resistance trained males.

Moulton, Christopher J.

The effects of creatine monohydrate supplementation on creatine transporter activity and creatine metabolism in resistance trained males.

dc.contributor.advisor	Willoughby, Darryn Scott, 1963-
dc.contributor.author	Moulton, Christopher J.
dc.contributor.department	Health, Human Performance and Recreation.	en
dc.contributor.other	Baylor University. Dept. of Health, Human Performance and Recreation.	en
dc.date.accessioned	2008-10-15T14:27:54Z
dc.date.available	2008-10-15T14:27:54Z
dc.date.copyright	2008-08
dc.date.issued	2008-10-15T14:27:54Z
dc.description	Includes bibliographical references (p. 73-77)	en
dc.description.abstract	Creatine is a nutritional supplement that is used for its potential performance enhancing (ergogenic) benefits. It constitutes an important component of the immediate energy system, by which ATP is regenerated during intense physical activity. Oral creatine supplementation has been shown to provide numerous benefits, including increases in lean muscle mass, muscular strength, and enhanced performance in various athletic capacities. The creatine transporter is a transmembrane protein that mediates the entry of creatine from the circulation into the muscle cell. Little is understood about the importance of the creatine transporter in controlling the uptake and regulation of creatine within human skeletal muscle. This study attempts to characterize the specific variations in creatine receptor activity and concurrent creatine metabolism in human skeletal muscle in response to a regimen of oral creatine supplementation including a one week loading phase, a four week maintenance phase, and a four week washout phase. Supplementation induced significant increments in total body mass (p = 0.03) and lean body mass (p = 0.01). A moderate effect size (d = 0.51) was found for strength increase, which suggests that the study was underpowered to detect a significant difference in strength increase. There appeared to be no effect of supplementation on intramuscular creatine; however, these data were subject to large measurement error and are not likely accurate. There was no apparent effect on creatine transporter mRNA or creatine transporter content when measured after the loading phase, during and after the maintenance phase, and after the washout phase.	en
dc.description.degree	M.S. Ed.	en
dc.description.statementofresponsibility	by Christopher J. Moulton.	en
dc.format.extent	x, 77 p. : ill.	en
dc.format.extent	155067 bytes
dc.format.extent	240802 bytes
dc.format.extent	73920 bytes
dc.format.mimetype	application/pdf
dc.format.mimetype	application/pdf
dc.format.mimetype	application/pdf
dc.identifier.uri	http://hdl.handle.net/2104/5243
dc.language.iso	en_US	en
dc.rights	Baylor University theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact librarywebmaster@baylor.edu for inquiries about permission.	en
dc.rights.accessrights	Worldwide access	en
dc.subject	Creatine -- Physiological effect.	en
dc.subject	Isometric exercise -- Physiological aspects.	en
dc.subject	Musculoskeletal system -- Metabolism.	en
dc.subject	Dietary supplements -- Physiological aspects.	en
dc.subject	Biological transport -- Physiology.	en
dc.title	The effects of creatine monohydrate supplementation on creatine transporter activity and creatine metabolism in resistance trained males.	en
dc.type	Thesis	en