Effects of Streptozotocin-Induced Diabetes on Astrocytic Activation in the Hippocampus & Hypothalamus

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dc.contributor.advisorVichaya, Elisabeth
dc.contributor.authorTadiparthi, Amoli
dc.contributor.departmentBiology.en_US
dc.date.accessioned2023-01-11T20:10:41Z
dc.date.available2023-01-11T20:10:41Z
dc.date.copyright2022-12-07
dc.date.issued2023-01-11
dc.description.abstractDiabetes is a metabolic disorder associated with insulin dysregulation affecting over 422 million people worldwide. This dysregulation leads to hyperglycemia -high blood glucose- which is associated with various comorbid diseases including depression and Alzheimer’s Disease. These comorbidities are presumably associated with hyperglycemia-induced brain changes. Given the role of astrocytes in glucose uptake, they provide a logical target. However, the data regarding their response is mixed. I sought to determine if astrocytes had increased reactively at a time in which the lab observes behavioral changes. Specifically, I evaluated GFAP staining of healthy control, STZ-induced hyperglycemic, and (as a positive control) lipopolysaccharide treated mice. I hypothesized that hyperglycemia would increase astrocytic reactivity in the hippocampus. However, the data indicate a trend toward a decline in astrocytic reactivity. Further research is necessary to determine if this astrocytic response to hyperglycemia is time-dependent or if the behavioral changes are driven by other cell populations.en_US
dc.identifier.urihttps://hdl.handle.net/2104/12136
dc.language.isoen_USen_US
dc.rightsBaylor University projects are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. Contact libraryquestions@baylor.edu for inquiries about permission.en_US
dc.rights.accessrightsNo access - Contact librarywebmaster@baylor.eduen_US
dc.titleEffects of Streptozotocin-Induced Diabetes on Astrocytic Activation in the Hippocampus & Hypothalamusen_US
dc.typeThesisen_US

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